Clinicaltrials.gov was searched for registered study protocols. The keyword phrases “palmitoylethanolamide” and “discomfort” resulted in thirteen entries, of which 3 ended up completed. None of them fulfilled our eligibility standards. The datasets created and/or analyzed in the course of The present review are offered through the corresponding writer on https://mitradine09785.newsbloger.com/31210259/detailed-notes-on-palmitoylethanolamide