If a guardian of your proband is known to have the pathogenic variant recognized while in the proband, the danger to your sibs of inheriting the pathogenic variant is 50%. As a result of diminished penetrance, sibs who inherit the pathogenic variant may or may not create aHUS (see Penetrance). https://industrial-chiller-hire09641.dm-blog.com/32841217/the-5-second-trick-for-ahu-hire