Study into conolidine has led to discovery of an opioid receptor in your body called ACKR3/CXCR7. ACKR3 seems to be by far the most sought after target for conolidine, which also disregards another 4 classical opioid receptors(3). thank you.. A: There is proscribed info on contraindications in between Conolidine https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers